The Protective effect of Theophline in Cisplatin Nephrotoxicity
Seyed Seifollah Beladi Mousavi Department of Nephrology Jundishapur University of Medical Sciences, Ahwaz, Iran
Abstract:
Introduction: Cisplatin is a potent and a major antineoplastic drug in the treatment of a broad spectrum of malignancies. However its clinical use is limited by renal tubular dysfunction that occurred in significant perscent of patients and aim of the present study was to evaluate the possible protective effect of theophyline in prevention of cisplatin-induced nephrotoxicity.
Materials and Methods:. The trial design was prospective, randomized, double blinded and placebo controlled. Chemotherapic patients that they were received cisplatin at a dosage of at least 50 mg/m2 alone or combined with other chemotherapy agent were included in the study. We randomizely divided our patints in two groups. In group 1 (n=38), placebo was advised; in group 2, patients recived aminophyline as an intravenous loading dose, followed by theophyline in a dose of 200mg three times daily orally for 4 consecutive days.
Results: In overall 76 patients, Group 1, n=38; 22 males and 16 Females, Group 2, n=38; 26 males and 12 Females, were included in the study. The mean age and mean dose of cisplatine were 51±17.6 years and 86.71±43.18 mg respectively. The prevalence of cisplatine nephrotoxicity in group 1 and 2 were 7.9 and 5.3 perscent and there was no significant difference between them (p=1). There also were no significant association between cisplatine nephrotoxicity and different age (p=0.1), males and females (p=0.64) and mean dose ofcisplatine (p=0.8).
Conclusion: These results indicate that prophylactic application of aminophyline and theophyline has not a protective effect against cisplatin nephrotoxicity.
